Anticonvulsant activities of myo-inositol and scyllo-inositol on pentylenetetrazol induced seizures
نویسندگان
چکیده
Myo-inositol (MI) and its isomers are used for the treatment of various neuropathological conditions. The purpose of the present research was to study anticonvulsant properties of MI and scyllo-inositol (SCI) on pentylenetetrazol (PTZ) induced seizures in rats. Half an hour after treatment with MI (30 mg/kg) or SCI (5 mg/kg) seizures were induced in Wistar rats with PTZ (60 mg/kg). Control animals were treated either by normal saline or mannitol (control polyol of the same molecular weight, 30 mg/kg), given at the same time interval before PTZ injection, as MI/SCI groups. The anticonvulsant effects of MI/SCI treatment were assessed by the latent period (the time from PTZ-injection to the onset of first seizures), and the duration and severity (score) of seizures. The mortality rate was also assessed. Both MI and SCI treatment significantly reduced the seizure score, seizure duration and increased the latent period. These data suggest for strong potential of MI and SCI as the agents of antiepileptic therapy.
منابع مشابه
Synthesis of all possible regioisomers of scyllo-inositol phosphate.
scyllo-Inositol is the all equatorial stereoisomer of myo-inositol. All possible 12 regioisomers of scyllo-inositol phosphate were synthesized for the first time via a scyllo-inositol benzoate intermediate, which was derived from a myo-inositol derivative. The stereoinversion of myo-inositol into scyllo-inositol was accomplished by Mitsunobu reaction of the vicinal cis-diol. The requisite inter...
متن کاملA review on the role of inositol in aquaculture
Inositol is usually classified as an essential vitamin for most animals, and is recognised as a part of the B-complex vitamins. Among all other inositol isomer forms, myo-inositol possesses biological activity. It is found in the brain, skeletal, heart, and main reproductive tissues and exists as a structural component of phosphatidylinositol in biological cell membranes. Myo-inositol, also act...
متن کاملA cell factory of Bacillus subtilis engineered for the simple bioconversion of myo-inositol to scyllo-inositol, a potential therapeutic agent for Alzheimer's disease
BACKGROUND A stereoisomer of inositol, scyllo-inositol, is known as a promising therapeutic agent for Alzheimer's disease, since it prevents the accumulation of beta-amyloid deposits, a hallmark of the disease. However, this compound is relatively rare in nature, whereas another stereoisomer of inositol, myo-inositol, is abundantly available. RESULTS Bacillus subtilis possesses a unique inosi...
متن کاملMyo-inositol transport in Saccharomyces cerevisiae.
myo-Inositol uptake in Saccharomyces cerevisiae was dependent on temperature, time, and substrate concentration. The transport obeyed saturation kinetics with an apparent Km for myo-inositol of 0.1 mM, myo-Inositol analogs, such as scyllo-inositol, 2-inosose, mannitol, and 1,2-cyclohexanediol, had no effect on myo-inositol uptake, myo-Inositol uptake required metabolic energy. Removal of D-gluc...
متن کاملEnzymatic fluorometric assay for myo-inositol trisphosphate.
The determination of myo-inositol trisphosphate by an enzymatic fluorometric assay is presented. The method involves the acid extraction of water-soluble inositol polyphosphates followed by separation by anion-exchange chromatography. Samples are subsequently neutralized by passage over a Dowex Cl- resin and elution with lithium chloride. Samples are then desalted with ethanol. Following dephos...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Seizure
دوره 20 شماره
صفحات -
تاریخ انتشار 2011